您现在的位置： 首页   -  产品中心   -  免疫学   -   抗体
PAPP-A Recombinant Rabbit mAb (SDT-226-46)

PAPP-A Recombinant Rabbit mAb (SDT-226-46)

货号: S0B0062
价格: 600
规格: 25μl
介绍: -
其他: -
产品规格

  • 宿主来源

    Rabbit

  • 抗原名称

    PAPP-A

  • 分子别名

    Pappalysin-1, IGFBP-4ase

  • 免疫原

    Recombinant Protein

  • Accession

    Q13219

  • 克隆号

    SDT-226-46

  • 抗体类型

    Rabbit mAb

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 浓度

    0.25 mg/ml

  • 性状

    Liquid

  • 缓冲体系

    PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied

稀释度
应用 稀释度
IHC-P 1:1000
背景介绍

  • PAPP-A is a proteolytic enzyme that was discovered to increase local insulin-like growth factor (IGF) availability for receptor activation through cleavage of inhibitory IGF binding proteins (IGFBPs). Reduced IGF signaling has been associated with increased lifespan and healthspan.
    Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF [PMID: 28035757 IF: 8.0 Q1 ].

  • 免疫组化

    • IHC shows positive staining in paraffin-embedded human placenta. Anti-PAPP-A antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
    • IHC shows positive staining in paraffin-embedded human placenta. Anti-PAPP-A antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
    • Negative control: IHC shows negative staining in paraffin-embedded human testis. Anti-PAPP-A antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
    • Negative control: IHC shows negative staining in paraffin-embedded human stomach. Anti-PAPP-A antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
    • Negative control: IHC shows negative staining in paraffin-embedded human colon cancer. Anti-PAPP-A antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
    • Negative control: IHC shows negative staining in paraffin-embedded human hepatocellular carcinoma. Anti-PAPP-A antibody was used at 1/1000 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.