EDNRB protein with egfp-Flag-His tag, nine mutants and tev site
75-90 kDa (Reducing)
10 mM Hepes, pH 7.5, 200 mM NaCl, 0.01 % LMNG, 0.001 % CHS.
·6 months from date of receipt, -60 to -80 °C as supplied.
·about 3 days in 2 to 8 °C.
·Please avoid repeated freeze-thaw cycles.
1. Ji, Yujie, et al. "Structural basis of peptide recognition and activation of endothelin receptors." Nature Communications 14.1 (2023): 1268.
Endothelin Receptor B (EDNRB) is a G protein-coupled receptor (GPCR) whose activity and function are regulated by G proteins. These G proteins activate a phosphatidylinositol-calcium second messenger system. EDNRB is widely expressed throughout the human body and plays a crucial role in regulating various physiological activities.
EDNRB binds to endothelin (ET) ligands and transmits signals into the cell via an intracellular Ca²⁺/phospholipid-dependent protein kinase second messenger system. This process promotes the rapid release of calcium from the endoplasmic reticulum and sarcoplasmic reticulum, facilitating downstream signaling events.
Endothelin exerts its biological functions through its receptors, such as EDNRB. Together, endothelin and its receptors (ETRs) form the endothelin axis. The endothelin axis has been implicated in various physiological and pathological processes. In the context of oncology, the endothelin axis exhibits pro-tumor effects, promoting tumor growth, metastasis, anti-apoptosis, and angiogenesis.
2μg (R: reducing condition, N: non-reducing condition).
The purity of EDNRB protein egfp-Flag-His tag (nine mutants, detergent) Protein his tag thrombin site in detergent is greater than 90% as determined by SEC-HPLC.
Immobilized EDNRB Rabbit pAb (A2908) at 0.5μg/mL (100μL/well) can bind EDNRB protein egfp-Flag-His tag (nine mutants, detergent), Human with EC50 of 41.30-67.52ng/mL.
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