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IGFBP3 Recombinant rabbit mAb (SDT-086-63)

IGFBP3 Recombinant rabbit mAb (SDT-086-63)

货号: S0B0015
价格: 600
规格: 25μl
介绍: -
其他: -
产品规格
  • 宿主来源

    Rabbit
  • 抗原名称

    IGFBP3
  • 分子别名

    Insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3
  • 免疫原

    Recombinant Protein
  • 细胞定位

    Secreted
  • Accession

    P17936
  • 克隆号

    SDT-086-63
  • 抗体类型

    Rabbit mAb
  • 应用

    WB
  • 反应种属 ?

    Hu
  • 纯化方式

    Protein A
  • 浓度

    0.5 mg/ml
  • 性状

    Liquid
  • 缓冲体系

    PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
  • 储存条件

    12 months from date of receipt / reconstitution, -20 °C as supplied
稀释度
应用 稀释度
WB 1:1000
背景介绍
  • Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF binding proteins. IGFBP-3 was first isolated, characterized, and quantitated in human plasma, in 1986. It has well-documented functions in the circulation, in the extracellular environment, and inside cells. It is the main IGF transport protein in the bloodstream, where it carries the growth factors predominantly in stable complexes that contain the binding protein, either IGF-1 or IGF-2, and a third protein called the acid-labile subunit or ALS. IGFBP-3 levels in human serum are, like IGF-1, dependent on growth hormone (GH); for example, serum IGFBP-3 is increased in acromegaly and low in GH-deficient children. However, IGFBP-3 gene expression in human liver is GH-independent. Because it is stabilized in human serum by forming complexes with IGF-1 and ALS, which are both GH-dependent, serum IGFBP-3 also appears regulated by GH. Its production by some non-hepatic tissues may also be directly GH-regulated. Immunoassays for serum IGFBP-3 are often used as part of the diagnosis of childhood GH-deficiency.
  • 免疫印迹

    • WB result of IGFBP3 Rabbit mAb                

      Primary antibody: IGFBP3 Rabbit mAb at 1/1000 dilution
      Lane 1: human serum lysate 20 µg
      Secondary antibody: Goat Anti-Rabbit IgG, (H+L), HRP conjugated at 1/10000 dilution
      Predicted MW: 41 kDa
      Observed MW: 40 kDa