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Biotinylated 4-1BB/TNFRSF9 Fc&Avi Tag Protein, Cynomolgus

Biotinylated 4-1BB/TNFRSF9 Fc&Avi Tag Protein, Cynomolgus

货号: UA010955
价格: 2300
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Cynomolgus

  • 分子别名

    4-1BB, TNFRSF9, CDw137, ILA, CD137

  • Accession

    A9YYE7

  • 表达序列

    Leu24-Gln186, with hIgG Fc &Avi

  • 表达宿主

    HEK293

  • 分子量

    55-70kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & RP-HPLC

  • 内毒素含量

    <1EU/μg

  • 活性

    Immobilized 4-1BB Ligand/TNFSF9 Fc Chimera , Cynomolgus at 2.0μg/mL (100μL/well) can bind Biotinylated 4-1BB/TNFRSF9 Fc&Avi Tag, Cynomolgus (Cat. No. UA010955) with EC50 of 8.45-11.22ng/mL.

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, 5% trehalose, PH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90. 2. Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.

  • 稀释度

背景介绍

  • CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. The best characterized activity of CD137 is its costimulatory activity for activated T cells.

  • 电泳JSON

  • 反相高效液相色谱JSON(RP-HPLC)

  • ELISA

    • Immobilized 4-1BB Ligand/TNFSF9 Fc Chimera , Cynomolgus at 2.0μg/mL (100μL/well) can bind Biotinylated 4-1BB/TNFRSF9 Fc&Avi Tag, Cynomolgus (Cat. No. UA010955) with EC50 of 8.45-11.22ng/mL.