Glu33-Ser190
19kDa
50mM Tris, 300mM NaCl, pH8.0
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1、Sullivan A R. et al. (2014) CSF-1R Signaling in Health and Disease: A Focus on the Mammary Gland. J Mammary Gland Biol Neoplasia. 19: 149-159.
2、Griffin J D. et al. (1990) The biology of GM-CSF: regulation of production and interaction with its receptor. Int J Cell Cloning. S1: 35-44.
Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), is a hematopoietic growth factor. It can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages. M-CSF is mainly produced by monocytes, macrophages, fibroblasts, and endothelial cells. M-CSF interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of of several diseases, including breast and endometrial cancers. The biological activity of human M-CSF is only active in the disulfide-linked dimeric form, which is bonded at Cys63.
Immobilized M-CSF Protein, Human (Cat. No. UA040042) at 0.5μg/mL (100μL/well) can bind M-CSFR Fc Chimera Protein, Human (Cat. No. UA010186) with EC50 of 33.09-51.56ng/mL.
Anti-His antibody Immobilized on CM5 Chip captured M-CSFR His Tag, Human (Cat. No. UA010208), can bind M-CSF, Human (Cat. No. UA040042) with an affinity constant of 10.76nM as determined in SPR assay.
Anti-His antibody Immobilized on CM5 Chip captured M-CSFR His Tag, Cynomolgus (Cat. No. UA010204), can bind M-CSF, Human (Cat. No. UA040042) with an affinity constant of 0.3μM as determined in SPR assay.
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