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Human Lumican, His tag

Human Lumican, His tag

货号: S0A0021
价格: 500
规格: 25μg
介绍: -
其他: -
产品规格
  • 物种

    Human
  • 分子别名

    Keratan sulfate proteoglycan lumican (KSPG lumican)
  • Accession

    P51884
  • 表达序列

    Protein sequence(P51884, Gln19-Asn338, with C-10*His)
    QYYDYDFPLSIYGQSSPNCAPECNCPESYPSAMYCDELKLKSVPMVPPGIKYLYLRNNQIDHIDEKAFENVTDLQWLILDHNLLENSKIKGRVFSKLKQLKKLHINHNNLTESVGPLPKSLEDLQLTHNKITKLGSFEGLVNLTFIHLQHNRLKEDAVSAAFKGLKSLEYLDLSFNQIARLPSGLPVSLLTLYLDNNKISNIPDEYFKRFNALQYLRLSHNELADSGIPGNSFNVSSLVELDLSYNKLKNIPTVNENLENYYLEVNQLEKFDIKSFCKILGPLSYSKIKHLRLDGNRISETSLPPDMYECLRVANEVTLNGGGGSHHHHHHHHHH

  • 表达宿主

    HEK293
  • 分子量

    Theoretical: 38.3kDa Actual: 46kDa
  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg
  • 标记

    Unconjugated
  • 标签

    His Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
  • 储存条件

    • 12 months from date of receipt, -20 ℃ to -70 °C as supplied.
    • 1 month, 2 to 8 °C under sterile conditions after reconstitution.  
    • Please avoid repeated freeze-thaw cycles. 
  • 稀释度

背景介绍
  • Lumican is a member of the small leucine-rich proteoglycan family. It is present in numerous extracellular matrices of different tissues, such as muscle, cartilage, and cornea. In skin, lumican is present as a glycoprotein. It plays a critical role in collagen fibrillogenesis, as shown by knocking out of its gene in mice. A direct link between lumican expression and melanoma progression and metastasis has been demonstrated. Lumican was shown to impede tumour cell migration and invasion by directly interacting with the α2β1 integrin. In addition, an active sequence of the lumican core protein, called lumcorin, was identified as being responsible for inhibition of melanoma cell migration. Lumican was also shown to exert angiostatic properties by downregulating the proteolytic activity associated with endothelial cell membranes, particularly matrix metalloproteinase (MMP)-14 and MMP-9. 

  • 电泳JSON

    • 2μg (R: reducing conditions)