1.Binder NK, Evans J, Salamonsen LA, Gardner DK, Kaitu'u-Lino TJ, Hannan NJ. Placental growth factor is secreted by the human endometrium and has potential important functions during embryo development and implantation. PLoS ONE 2016; 11(10): e0163096.
Placental growth factor (PlGF-1) is a member of the vascular endothelial growth factor (VEGF) family and is predominantly expressed in the placenta, although it is also expressed at low levels in many other tissues, including the heart, lung, thyroid, liver, skeletal muscle and bone. The human PlGF gene is located on chromosome 14q14 and encodes 4 isoforms of PlGF. The protein is secreted as a glycosylated homodimer and PlGF-1 and -3 are diffusible isoforms whereas PlGF-2 and PlGF-4 have heparin binding domains. Endometrial tissue during the secretory phase of the human menstrual cycle has been shown to secrete PlGF. The main role of PlGF in tissues other than the placenta is angiogenesis in response to pathological ischaemia or injury. In tumour cells, PlGF expression is part of the angiogenic switch that supports tumour vascularisation.
Measured in a cell proliferation assay using MDA‑MB‑231 human breast cancer cells..The EC50 for this effect is less than 5μg/ml.
1μg (R: reducing condition, N: non-reducing condition).
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