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Biotinylated GLP-1R His&Avi Tag Protein, Human

货号: UA010807

价格: 2450

规格: 25μg

介绍: -

其他: -

产品规格

物种

Human
分子别名

GLP-1 receptor; GLP1R; GLP-1R; GLP-1-R; glucagon-like peptide 1 receptor; MGC138331
Accession

P43220-1
表达序列

Ala21-Glu139, with C-terminal His and Avi tag
表达宿主

HEK293
分子量

25-33kDa (Reducing)
纯度

＞95% by SDS-PAGE
内毒素含量

<1EU/μg
标记

Biotin
标签

Avi Tag, His Tag
性状

Lyophilized Powder
缓冲体系

PBS, pH7.4.
溶解方法

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用

1. Article Open Access Published: 09 March 2020Nature Communications volume 11, Article number: 1272 (2020) Cite this article.

背景介绍

Glucagon-like peptide-1 receptor (GLP-1R) is a class B G-protein-coupled receptor. Human GLP-1R consists of an N-terminal, extracellular domain (ECD) containing 6 conserved cysteine residues and a transmembrane domain with seven membrane-spanning alpha-helices, characteristic of GPCRs. Activation of GLP-1R signaling regulates secretion of insulin from pancreatic beta -cells in a glucose-dependent manner. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man.