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MMP-9 His Tag Protein, Human

MMP-9 His Tag Protein, Human

货号: UA011205
价格: 1600
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    Type V Collagenase，Gelatinase B，EC 3.4.24.35，MANDP2，Matrix Metalloproteinase 9，CLG4B，MMP9，Matrix Metallopeptidase 9，Matrix Metalloproteinase 9 (Gelatinase B， 92kDa Gelatinase， 92kDa Type IV Collagenase)，GELB，Matrix Metalloproteinase-9，92 KDa Type IV Collagenase，Macrophage Gelatinase，92 kDa gelatinase，MMP-9，Matrix Metallopeptidase 9 (Gelatinase B， 92kDa Gelatinase， 92kDa Type IV Collagenase)，EC:3.4.24.35，EC 3.4.24

  • Accession

    P14780-1

  • 表达序列

    Ala20-Pro469 with His Tag at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    55-72kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. 
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.  
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.St-Pierre Y, et al. (2003) Emerging features in the regulation of MMP-9 gene expression for the development of novel molecular targets and therapeutic strategies. Curr Drug Targets Inflamm Allergy. 2(3): 206-15.
    2.St-Pierre Y, et al. (2004) Regulation of MMP-9 gene expression for the development of novel molecular targets against cancer and inflammatory diseases. Expert Opin Ther Targets. 8(5): 473-89.
    3.Chakrabarti S, et al. (2005) Matrix metalloproteinase-2 (MMP-2) and MMP-9 in pulmonary pathology. Exp Lung Res. 31(6): 599-621.

  • 稀释度

背景介绍

  • Matrix metalloproteinases (MMPs) are neutral proteases involved in extracellular matrix (ECM) breakdown and remodeling during physiological processes like morphogenesis, angiogenesis, and tissue repair, as well as in pathological conditions such as inflammation, arthritis, and cancer. MMP9, or 92-kDa gelatinase B/type IV collagenase, is secreted by neutrophils, macrophages, and transformed cells. It is critical for tissue remodeling in inflammatory processes and is a key product of macrophages and neutrophils. MMP9 is also released by lymphocytes and stromal cells in response to inflammatory cytokines or integrin-mediated signals. Excessive MMP9 production is linked to tissue damage and degenerative disorders, making its regulation a focus for therapeutic development. Its overexpression in cancer and inflammatory conditions highlights the importance of understanding the mechanisms controlling its expression to identify potential therapeutic targets.

  • 电泳JSON

    • 1μg (R: reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of MMP-9 His Tag Protein, Human is greater than 95% as determined by SEC-HPLC.

  • ELISA

    • Immobilized MMP-9 His Tag Protein, Human (Cat. No. UA011205) at 2.0μg/mL (100μL/well) can bind MMP9 Recombinant Rabbit mAb (SDT-368-16) (Cat. No. S0B2297) with EC50 of 0.95-1.48ng/mL.