Ser17-Glu460 with His Tag at the C-terminus
PBS, PH7.4,5% trehalose
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Arch Esp Urol. 2025 Jan;78(1):84-92.
World J Gastrointest Oncol. 2025 Feb 15;17(2):97858.
ANGPTL3, also known as angiopoietin-related protein 3 or angiopoietin-5 (ANGPT5), is a secreted factor in the angiopoietin-like family. Predominantly expressed in the liver, it features a signal peptide, an N-terminal coiled-coil domain, and a C-terminal fibrinogen-like domain. The fibrinogen-like domain binds alpha-5/beta-3 integrins, promoting endothelial cell adhesion and migration, and may regulate angiogenesis. ANGPTL3 also inhibits lipoprotein lipase and endothelial lipase, increasing plasma triglycerides and HDL cholesterol in rodents. By blocking endothelial lipase, it raises HDL-phospholipid levels, enhancing cholesterol efflux.
1μg (R: reducing condition, N:non-reducing condition).
The purity of Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human is more than 90% determined by SEC-HPLC.
Immobilized Angiopoietin-like 3/ANGPTL3 His Tag Protein, Human (Cat. No. UA011204) at 2.0μg/mL (100μL/well) can bind ANGPTL3 Recombinant Rabbit mAb (SDT-425-59) (Cat. No. S0B3204) with EC50 of 0.96-1.35ng/mL.
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