Ser22-Asp182&Leu22-Pro170, with 6His tag at the C-terminus
30-40 kDa, reducing conditions
PBS, 5% Trehalose, pH7.4.
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt.
Reconstituted protein solution can be stored at 2-8°C for 2-7 days.
Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
CD8 is a heterodimeric membrane glycoprotein on MHC class I-restricted T lymphocytes that cooperates with the alpha beta CD3 TCR in the recognition of MHC class I molecules presenting antigenic peptides. Cell surface CD8 molecules exist as either alpha/alpha homodimers or alpha/beta heterodimers, and most CD8+ T cells that undergo differentiation in the thymus express alpha/beta heterodimers. The CD8 b chain appears to be important for the thymic maturation of CD8+ T cells, because the number of mature CD8 single-positive T cells is decreased in CD8b gene-disrupted mice and most CD8+ T cells among gut intraepithelial lymphocytes in thymectomized mice express CD8 alpha/alpha homodimers.
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