Cys20-Pro236 with hIgG1 Fc at the C-terminus
PBS PH7.4 , 5% trehalose
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Ren Y, Xue M, Hui X, Liu X, Farooq MA, Chen Y, Ji Y, Duan Y, Ajmal I, Yao J, Jiang W. Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer. Pharmacol Res. 2025 Feb;212:107637.
Human interleukin-21 receptor (IL21R), also known as CD360 or NILR, is a type I cytokine receptor belonging to the type 4 subfamily. It contains two fibronectin type-III domains and is selectively expressed in lymphoid tissues, with the highest expression in the thymus and spleen. IL21R is crucial for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells, as it transduces the growth-promoting signals of interleukin-21 (IL-21).
1μg (R: reducing condition, N: non-reducing condition).
The purity of IL-21R Fc Chimera Protein, Human is more than 90% determined by SEC-HPLC.
Immobilized IL-21 Protein, Human (Cat. No. UA040009) at 5.0μg/mL (100μL/well) can bind IL-21R Fc Chimera Protein, Human (Cat. No. UA011187) with EC50 of 15.71-18.64ng/mL.
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