Claudin 1 (full ength) with His-EGFP-Twinstrep tag at the C-terminus
50mMTris, PH7.5,150mMNaCl,0.05%DDM
·6 months from date of receipt, -60 to -80 °C as supplied.
·about 3 days in 2 to 8 °C.
·Please avoid repeated freeze-thaw cycles.
Zuo D, Zhang J, Liu T, et al. Claudin‐1 Is a Valuable Prognostic Biomarker in Colorectal Cancer: A Meta‐Analysis[J]. Gastroenterology Research and Practice, 2020, 2020(1): 4258035.
Claudins are major components of tight junction complexes that regulate epithelial permeability. Claudin 1 (CLDN1), a member of the Claudin family, is a key membrane protein in tight junctions. CLDN1 is essential for preventing the paracellular diffusion of small molecules through tight junctions in the epidermis, maintaining the skin's normal barrier function. Loss-of-function mutations in CLDN1 result in neonatal ichthyosis-sclerosing cholangitis syndrome. Studies have shown that CLDN1 plays a regulatory role in cancer and may serve as a potential therapeutic target. Additionally, evidence indicates that Claudins are important in tumor immunotherapy and have significant therapeutic potential. The Claudin 1 protein product may enhance the development of drug discovery efforts related to its therapeutic potential.
1μg (R: reducing condition, N: non-reducing condition).
Immobilized Claudin-1 His-EGFP-Twinstrep tag Protein, Human (Detergent) (Cat. No. UA060010) at 2 μg/mL (100 μL/well) on a Nickel Coated plate can bind CLDN1 Recombinant rabbit mAb PBS (SDT-025) with EC50 of 9.27-13.15ng/mL.
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