Phe20-Arg356 with Human IgG1 Fc at C-Terminus
72-95kDa (Reducing)
PBS, PH7.4,5% trehalose
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Parnet, P. et al. (1996) J. Biol. Chem. 271:3967.
Interleukin 18 (IL-18) is a member of the IL-1 family of cytokines and shares numerous immunoregulatory functions with IL-12. The functional IL-18 receptor complex consists of two subunits: IL-18Rα (also known as IL-1R5 or IL-1Rrp) and IL-18Rβ (also known as IL-1R7 or AcPL). Both subunits belong to the IL-1 receptor superfamily. IL-18R is widely expressed in various tissues, including the spleen, thymus, leukocytes, liver, lung, heart, small and large intestines, prostate, and placenta.
The IL-18 receptor complex is responsible for binding the pro-inflammatory cytokine IL-18, but not IL-1α or IL-1β. It is involved in IL-18-mediated IFNγ synthesis from T-helper 1 (Th1) cells and contributes to IL-18-induced cytokine production, either independently of SLC12A3 or as a complex with SLC12A3.
1μg (R: reducing condition, N: non-reducing condition).
96.3%
When IL-18Rβ/IL-1R7 Fc Chimera Protein, Human (Cat. No. UA010873) is immobilized at 2.0µg/mL (100 µL/well), in the present of IL-18, Human (Cat. No. UA040111), IL-18Rα/IL-1R5 His Tag Protein, Human (Cat. No. UA010914) binds with an ED50 of 40.10-49.63ng/mL.
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