Met113-Leu261, with C-His tag
Predicted MW: 17.9 kDa Observed MW: 18, 19 kDa
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
CD154, also called CD40 ligand, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and integrin αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (TFH cells). On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome. Absence of CD154 also stops the formation of germinal centers and therefore prohibiting antibody affinity maturation.
2μg（R: reducing conditions）
Immobilized CD40 Fc Chimera Protein, Human (Cat. No. UA010194) at 10 μg/mL (50 μL/well) can bind CD40 Ligand/TNFSF5, His tag Protein, Human with EC50 of 29.67-36.83 ng/ml.
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