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Endothelin B Receptor His Tag Protein, Human

Endothelin B Receptor His Tag Protein, Human

货号: UA011142
价格: 1800
规格: 25μg
介绍: -
其他: -
产品规格
  • 物种

    Human
  • 分子别名

    ABCDS, ET-B, ET-BR, ETB, ETB1, ETBR, ETRB, HSCR, HSCR2, WS4A
  • Accession

    NP_000106.1
  • 表达序列

    Glu27-Lys101 with His Tag at C-Terminus

  • 表达宿主

    HEK293
  • 分子量

    15-28kDa (Reducing)
  • 纯度

    >95% by SDS-PAGE & SEC-HPLC
  • 活性

    Immobilized Endothelin B Receptor His Tag Protein, Human (Cat. No. UA011142) at 2.0μg/mL (100μL/well) can bind EDNRB Rabbit pAb with EC50 of 6.38-8.77ng/mL.
  • 标记

    Unconjugated
  • 标签

    His Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    PBS, PH7.4, 5% trehalose
  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. 
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.  
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Maguire, J. J. & Davenport, A. P. Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. Br. J. Pharmacol. 171, 5555–5572 (2014)
    Davenport, A. P. et al. Endothelin. Pharmacol. Rev. 68, 357–418 (2016).

  • 稀释度

背景介绍
  • Endothelin receptors, specifically ETA and ETB, are class A G protein-coupled receptors (GPCRs) that are activated by the vasoactive peptide endothelins and play a role in blood pressure regulation. Selective signaling through the ETB receptor induces vasorelaxation, making selective ETB agonists potential candidates for improved anti-tumor drug delivery and neuroprotection.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of Endothelin B Receptor His Tag Protein, Human is more than 95% determined by SEC-HPLC.

  • ELISA

    • Immobilized Endothelin B Receptor His Tag Protein, Human (Cat. No. UA011142) at 2.0μg/mL (100μL/well) can bind EDNRB Rabbit pAb with EC50 of 6.38-8.77ng/mL.