Gly31-Ser347 with His Tag & Avi Tag at C-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Duan X, Zhang Z, Xu H, Zhang J, Yan Y, Yang X. Preclinical Evaluation of an Al18F-Radiolabeled Bicyclic Peptide Targeting Nectin-4. Mol Pharm. 2024 Dec 9.
Nectin-4, a member of the Nectin and nectin-like family of cell adhesion molecules, is highly expressed in normal embryonic and fetal tissues, with expression levels decreasing after reaching adulthood and being restricted in healthy adult tissues. Nectin-4 is overexpressed in various types of tumor cells and is known to promote tumor cell growth and proliferation. Solid tumors that frequently exhibit high Nectin-4 expression include bladder, pancreatic, triple-negative breast, non-small cell lung, stomach, esophageal, and ovarian cancers, among others.
Research has shown that Nectin-4 enhances tumor cell proliferation, differentiation, migration, and invasion by activating the PI3K/Akt signaling pathway, suggesting a significant role in cancer initiation and metastasis. These findings have prompted the development of drugs targeting Nectin-4 as a potential therapeutic strategy.
1μg (R: reducing condition, N: non-reducing condition).
The purity of Biotinylated Nectin-4 His&Avi Tag Protein, Mouse is more than 90% determined by SEC-HPLC.