Thr336-Arg455
15-16 kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in 4mM HCl after rapid centrifugation.
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Nature. 1994 Apr 14;368(6472):639-43.
Development. 1999 Mar;126(6):1305-15.
Growth differentiation factor 6 (GDF-6), also known as bone morphogenetic protein 13 (BMP-13), is a member of the transforming growth factor-beta (TGF-β) superfamily of cytokines that plays a critical role in skeletal development and joint maintenance. In humans, GDF-6 is expressed in various tissues, including cartilage, bone, and synovium, and is involved in regulating chondrogenesis, osteogenesis, and joint homeostasis. GDF-6 exerts its biological effects by binding to specific cell surface receptors, such as the BMP receptors, leading to the activation of downstream signaling pathways, including Smad and non-Smad pathways. Through its signaling activities, GDF-6 promotes the differentiation of mesenchymal stem cells into chondrocytes and osteoblasts, as well as the maintenance of cartilage integrity and joint function. GDF-6 is considered a key regulator of skeletal development and joint health, with implications for musculoskeletal disorders and regenerative medicine.
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The EC50 for this effect is less than 3μg/mL.
2μg (R: reducing condition, N: non-reducing condition).
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