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RANK L/TNFSF11(178aa) Protein, Human

RANK L/TNFSF11(178aa) Protein, Human

货号: UA040369
价格: 1080
规格: 10μg
介绍: -
其他: -
产品规格
  • 物种

    Human
  • 分子别名

    Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor (ODF); Osteoprotegerin ligand (OPGL); Receptor activator of nuclear factor kappa-B ligand (RANKL); TNF-related activation-induced cytokine (TRANCE);
  • Accession

    O14788
  • 表达序列

    Ile140-Asp317

  • 表达宿主

    E.coli
  • 分子量

    21 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.
  • 内毒素含量

    <0.1EU/μg
  • 活性

    EC50 < 1.0ng/ml
  • 标记

    Unconjugated
  • 标签

    No Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    20mM Sodium Citrate, pH 5.0
  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Cell. 2000 Sep 29;103(1):41-50.
    Genes Dev. 1999 Sep 15;13(18):2412-24.

  • 稀释度

背景介绍
  • Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as TNF-related activation-induced cytokine (TRANCE), is a cytokine that belongs to the tumor necrosis factor (TNF) superfamily. In humans, RANKL is primarily expressed by osteoblasts, T cells, and other immune cells, and plays a crucial role in regulating bone metabolism, immune function, and the development of mammary glands. RANKL functions by binding to its receptor RANK on the surface of osteoclast precursors, leading to the activation and differentiation of osteoclasts, which are responsible for bone resorption. Additionally, RANKL is involved in the regulation of T cell activation, dendritic cell function, and the formation of lactating mammary glands. Dysregulation of RANKL has been implicated in various bone-related diseases, such as osteoporosis and bone metastasis, as well as in immune disorders, highlighting the importance of RANKL in skeletal biology and immune regulation.

  • 生物活性JSON

    • Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The EC50 for this effect is less than 1ng/ml.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • >95% as determined by SEC-HPLC.