Ser74-Thr182
15-17 kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in 10mM HAc after rapid centrifugation.
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.
Genes Dev. 2008 May 15;22(10):1276-312.
Platelet-derived growth factor-BB (PDGF-BB) is a homodimeric isoform of the PDGF family of growth factors that plays a crucial role in regulating cell proliferation, migration, and survival. In rats, PDGF-BB is produced by various cell types, including platelets, endothelial cells, and smooth muscle cells, and acts on cells expressing PDGF receptors, such as PDGFR-α and PDGFR-β. Upon binding to its receptors, PDGF-BB activates intracellular signaling pathways, such as the Ras-MAPK and PI3K-Akt pathways, leading to cellular responses involved in tissue repair, angiogenesis, and fibrosis. PDGF-BB is known for its mitogenic and chemotactic effects on mesenchymal cells, including fibroblasts and smooth muscle cells, and plays a critical role in wound healing, tissue remodeling, and vascular development.
Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 5ng/ml.
2μg (R: reducing condition, N: non-reducing condition).
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