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Serpin G1/C1 Inhibitor His Tag Protein, Human

Serpin G1/C1 Inhibitor His Tag Protein, Human

货号: UA011146
价格: 680
规格: 25μg
介绍: -
其他: -
产品规格
  • 物种

    Human
  • 分子别名

    SERPING1, C1IN, C1-INH, C1IN, HAE1, HAE2
  • Accession

    P05155-1
  • 表达序列

    Asn23-Ala500 with His Tag at C-Terminus

  • 表达宿主

    HEK293
  • 分子量

    85-100kDa (Reducing)
  • 纯度

    >95% by SDS-PAGE &>90% by SEC-HPLC
  • 标记

    Unconjugated
  • 标签

    His Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    PBS, PH7.4, 5% trehalose
  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. 
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.  
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Mahajan SD, Aalinkeel R, Reynolds JL, Machhar JS, Ghebrehiwet B, Schwartz SA. Omics analysis reveals galectin-3 to be a potential key regulator of allergic inflammation in hereditary angioedema. J Allergy Clin Immunol Glob. 2024 Oct 18;4(1):100353.
    Akeret K, Thomson BR, Ghosh S, Nolte M, Fischer U, Humar R, Regli L, Schaer DJ, Hugelshofer M, Buzzi RM. C1-inhibitor to prevent intracerebral hemorrhage-related secondary brain injury. Fluids Barriers CNS. 2024 Nov 15;21(1):91.

  • 稀释度

背景介绍
  • Serpin G1, also known as C1-inhibitor (C1-INH), is a crucial regulator of the complement, coagulation, fibrinolytic, and contact systems. The levels of protease/C1-INH complexes in the blood correlate with the in vivo activation of these four cascade-like plasma enzyme systems. C1-INH inhibits the activated forms of C1r and C1s, which are part of the first complement component, thereby regulating complement activation. Synthesized in the liver, deficiencies in C1-INH are associated with hereditary angioneurotic edema (HANE).

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of Serpin G1/C1 Inhibitor His Tag Protein, Human is more than 90% determined by SEC-HPLC.