Tyr22-Gly538 with Human IgG1 Fc at C-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Nagy Á, Ulmert D, Zedan W, Storey CM, Park J, Geres S, Lückerath K, Sjöström K, Westin H, Peekhaus N, Thorek DL, Karlström AE, Altai M. Impact of site-specific conjugation strategies on the pharmacokinetics of antibody conjugated radiotherapeutics. Eur J Med Chem. 2024 Sep 30;280: 116927.
LRRC15, also known as LIB and hLib, is a leucine-rich repeat-containing protein that is highly expressed in various solid tumors. It is found on stromal fibroblasts in many solid tumors, including those of the breast, head and neck, lung, and pancreas, as well as directly on a subset of cancer cells of mesenchymal origin, such as sarcoma, melanoma, and glioblastoma. LRRC15 expression can be induced by TGFβ in activated fibroblasts (positive for α-smooth muscle actin, αSMA) and in mesenchymal stem cells. These collective findings suggest that LRRC15 serves as a novel cancer-associated fibroblast (CAF) and mesenchymal marker, making it a potential therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or those of mesenchymal origin.
1μg (R: reducing condition, N: non-reducing condition).
The purity of LRRC15/LIB Fc Chimera Protein, Human is more than 90% determined by SEC-HPLC.
Immobilized LRRC15/LIB Fc Chimera Protein, Human (Cat. No. UA011115) at 5.0μg/mL (100μL/well) can bind Biotinylated Samrotamab with EC50 of 4.51-6.99ng/mL.
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