Asp21-Lys80 with Human IgG1 Fc and His Tag at C-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Yanagisawa M, et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988;332(6163):411–415.
Endothelin (ET/EDN) receptors are members of the class A GPCR family and exist in two isoforms: type A (ETAR/EDNRA) and type B (ETBR/EDNRB). These receptors exhibit different affinities for three ligands—ET1, ET2, and ET3. ETAR demonstrates a significantly higher affinity for ET1 and ET2 compared to ET3, while ETBR binds all three ligands nonselectively. The binding affinity rank order for the ET-A receptor is: ET1 > ET2 >> ET3.
ETAR mediates its action by associating with G proteins, which activate a phosphatidylinositol-calcium second messenger system. Both angiotensin II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR) are G-protein-coupled receptors (GPCRs) found on the surface of various cell types, including immune cells, vascular smooth muscle cells, endothelial cells, and fibroblasts. These receptors are activated by endothelin 1 (ET1) and angiotensin II (AngII), respectively.
1μg (R: reducing condition, N: non-reducing condition).
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