Gly32-Ser692 with His Tag at C-Terminus
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Wang X, et al. (2018) Aplp2 modulates jnk-dependent cell migration in drosophila. Biomed Res Int 2018 7469714.
2.Han K, et al. (2017) Amyloid-precursor like proteins aplp1 and aplp2 are dispensable for normal development of the neonatal respiratory network. Front Mol Neurosci 10 189.
YWK-II protein/APLP2 is a member of an evolutionarily conserved APP family that includes amyloid precursor protein (APP) and amyloid precursor-like protein-1 (APLP1). YWK-II/APLP2 functions as a novel G(0)-protein-coupled receptor for Müllerian inhibiting substance (MIS) in cell survival. Human leukocyte antigen-B-associated transcript 3 (Bat3), an important regulator involved in apoptosis, can interact with YWK-II/APLP2 and enhance its stability by reducing its ubiquitylation and degradation by the ubiquitin-proteasome system. May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.
1μg (R: reducing condition, N: non-reducing condition).
The purity of APLP2/Amyloid-like protein 2 His Tag Protein, Human is greater than 95% as determined by SEC-HPLC.