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APLP2/Amyloid-like protein 2 His Tag Protein, Human

APLP2/Amyloid-like protein 2 His Tag Protein, Human

货号: UA011132
价格: 1480
规格: 25μg
介绍: -
其他: -
产品规格
  • 物种

    Human
  • 分子别名

    Amyloid beta precursor like protein 2, APLP2, APPH, CDEBP, APPL2
  • Accession

    Q06481-1
  • 表达序列

    Gly32-Ser692 with His Tag at C-Terminus

  • 表达宿主

    HEK293
  • 分子量

    80-100kDa (Reducing)
  • 纯度

    >95% by SDS-PAGE & SEC-HPLC
  • 内毒素含量

    <0.1EU/μg
  • 标记

    Unconjugated
  • 标签

    His Tag
  • 性状

    Lyophilized Powder
  • 缓冲体系

    PBS, PH7.4, 5% trehalose
  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. 
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.  
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Wang X, et al. (2018) Aplp2 modulates jnk-dependent cell migration in drosophila. Biomed Res Int 2018 7469714.
    2.Han K, et al. (2017) Amyloid-precursor like proteins aplp1 and aplp2 are dispensable for normal development of the neonatal respiratory network. Front Mol Neurosci 10 189.

  • 稀释度

背景介绍
  • YWK-II protein/APLP2 is a member of an evolutionarily conserved APP family that includes amyloid precursor protein (APP) and amyloid precursor-like protein-1 (APLP1). YWK-II/APLP2 functions as a novel G(0)-protein-coupled receptor for Müllerian inhibiting substance (MIS) in cell survival. Human leukocyte antigen-B-associated transcript 3 (Bat3), an important regulator involved in apoptosis, can interact with YWK-II/APLP2 and enhance its stability by reducing its ubiquitylation and degradation by the ubiquitin-proteasome system. May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of APLP2/Amyloid-like protein 2 His Tag Protein, Human is greater than 95% as determined by SEC-HPLC.