Leu20-Gly237 with Human IgG1 Fc at C-Terminus
55-70kDa (Reducing)
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
1.Philipson, L. et al., 2004, Curr. Top. Microbiol. Immunol. 273:87-111.
2.Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-1580.
CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family within the immunoglobulin (Ig) superfamily. It plays a crucial role in normal cardiac development in mice. CXADR is proposed to function as a homophilic cell adhesion molecule and is a component of the epithelial apical junction complex, which is essential for maintaining tight junction integrity. It is also likely involved in the transepithelial migration of polymorphonuclear leukocytes (PMNs).
The mature mouse CXADR structure comprises a 218 amino acid (aa) extracellular domain (ECD), which includes a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment, and a 17 aa intracellular domain. Notably, D1 is believed to be responsible for homodimer formation within tight junctions. The ECD of mouse CXADR shares 97% sequence identity with the corresponding regions of human CXADR and 9% sequence identity with those of rat CXADR.
1μg (R: reducing condition, N: non-reducing condition).
The purity of CXADR Fc Chimera Protein, Mouse is greater than 95% as determined by SEC-HPLC.
Immobilized Recombinant Mouse JAML/AMICA Protein (His Tag), HPLC-verified at 2.0μg/mL (100μL/well) can bind CXADR Fc Chimera Protein, Mouse (Cat. No. UA011124) with EC50 of 12.27-23.60 ng/mL.
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