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Flt-3/Flk-2 Protein, Human

Flt-3/Flk-2 Protein, Human

货号: UA040316
价格: 600
规格: 10μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2 (FLK-2); Fms-like tyrosine kinase 3 (FLT-3); Stem cell tyrosine kinase 1 (STK-1);

  • Accession

    P36888

  • 表达序列

    Asn27-Asn541, with C-terminal hIgG1 Fc.

  • 表达宿主

    HEK293

  • 分子量

    100-120 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 7-12 ng/ml.

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Immunity. 2002 Oct;17(4):463-72.

  • 稀释度

背景介绍

  • Fms-like tyrosine kinase 3 (Flt-3), also known as fetal liver kinase 2 (Flk-2), is a receptor tyrosine kinase that plays a critical role in hematopoiesis and immune cell development. Flt-3 is primarily expressed on hematopoietic stem cells and early progenitor cells, where it regulates cell proliferation, differentiation, and survival. Activation of Flt-3 by its ligand, Flt-3 ligand (Flt-3L), leads to the activation of downstream signaling pathways involved in hematopoietic cell growth and differentiation. Flt-3 is essential for the development of various immune cell lineages, including dendritic cells, natural killer cells, and B cells.

  • 电泳JSON

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • >95% as determined by SEC-HPLC.

  • ELISA

    • Measured by its binding ability in a functional ELISA. When Recombinant Human FLT3L is immobilized 2.5µg/mL (100 µl/well), Recombinant Human FLT3/FLK2 Fc binds with an EC50 of 0.007-0.012 ug/ml.