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Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human

Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human

货号: UA011222
价格: 2580
规格: 25μg
介绍: -
其他: -
产品规格

  • 物种

    Human

  • 分子别名

    IL6RA，IL6RQ，IL6Q，Interleukin-6 Receptor alpha Subunit，sIL6R，gp80，IL-6R subunit alpha，Membrane glycoprotein 80，IL6R，Interleukin 6 Receptor，IL-6 Receptor Subunit Alpha，CD126 Antigen，IL-6R 1，IL-6RA，Interleukin-6 Receptor Subunit Alpha，IL-6R-Alpha，IL-6R-1，CD126

  • Accession

    P08887-1

  • 表达序列

    Leu20-Pro365 with Human IgG1 Fc & Avi Tag at C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    72-95kDa (Reducing)

  • 纯度

    > 95 % as determined by SDS-PAGE & SEC-HPLC

  • 内毒素含量

    <1EU/μg

  • 活性

    Immobilized IL-6 Protein, Human (Cat. No. UA040052) at 2.0μg/mL (100μL/well) can bind Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human (Cat. No. UA011222) with EC50 of 8.02-11.36ng/mL.

  • 标记

    Biotin

  • 标签

    Human IgG1 Fc, Avi Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. 
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.  
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.M Hibi, M Murakami, M Saito, T Hirano, T Taga, TKishimoto. Molecular cloning and expression of an IL-6 signal transducer,gp130.Cell. 1990 Dec 21;63(6):1149-57.
    2. Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z.Targeting miR-10a-5p/IL-6Raxis for reducing IL-6-induced cartilage cell ferroptosis.Exp Mol Pathol. 2021Feb;118:104570. Cell., 63 (1990), pp. 1149-1157.

  • 稀释度

背景介绍

  • The interleukin-6 receptor (IL-6R) comprises an 80-kDa IL-6-binding protein (α chain/CD126) and gp130. CD126, a glycoprotein with the ligand-binding site, is part of the human IL-6R, which spans 468 amino acids, including a signal peptide, extracellular region, transmembrane domain, and a short cytoplasmic domain of 19, 339, 28, and 82 amino acids, respectively. IL-6R is present on multiple myeloma, hepatocellular carcinoma, prostate carcinoma, and epidermoid carcinoma cells. The IL-6/IL-6R pathway drives tumor growth, particularly in gliomas, making IL-6R a drug delivery target and a therapeutic target. Primary human cartilage cells express IL-6R, which is upregulated by IL-6, positioning cartilage cells as direct targets of IL-6.

  • 电泳JSON

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱JSON(SEC-HPLC)

    • The purity of Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human is greater than 95% as determined by SEC-HPLC.

  • ELISA

    • Immobilized IL-6 Protein, Human (Cat. No. UA040052) at 2.0μg/mL (100μL/well) can bind Biotinylated IL-6 R alpha/CD126 Fc&Avi Tag Protein, Human (Cat. No. UA011222) with EC50 of 8.02-11.36ng/mL.